TABLE 3.
Corresponding clinical and ancillary HPV testing of the consensus histology cases of CIN2 and CIN3 in which hrHPV detection by cobas HPV and/or AHPV tests was negative
| Paired test result | Patient age (yr) | Histology by: |
Clinical test result by: |
Ancillary test HPV type result bya: |
Test result interpretationb | ||||
|---|---|---|---|---|---|---|---|---|---|
| Consensus | Community | Cobas HPV | AHPV | HC2 | E6/E7 RNA sequencing (HPV RNA genotype) | Linear array | |||
| AHPV+/cobas− | 29 | CIN2 | CIN1 | − | + | + | 58 | 33, 54, 58 | False negative (cobas) |
| 37 | CIN3 | CIN3 | − | + | − | 18 | 18, 54 | False negative (cobas) | |
| 32 | CIN3 | CIN2 | − | + | + | NA | 82 | False negative (cobas)d or untargeted | |
| AHPV−/cobas+ | 22 | CIN3 | CIN3 | + (other) | − | NA | − | 39, 45 | False negative (AHPV) |
| 24 | CIN2 | CIN2 | + (HPV18) | − | + | − | 6, 61 | False negative (AHPV)c or untargeted | |
| 28 | CIN2 | CIN2 | + (other) | − | + | − | 52 | False negative (AHPV) | |
| AHPV−/cobas− | 20 | CIN2 | CIN1 | − | − | − | − | 70 | True negatived or untargetede |
| 22 | CIN2 | CIN1 | − | − | − | − | 53 | True negatived or untargetede | |
| 39 | CIN2 | Normal | − | − | − | − | 61 | True negatived or untargetede | |
| 30 | CIN3 | CIN3 | − | − | − | − | 82 | True negatived or untargetede | |
| 23 | CIN2 | CIN1 | − | − | + | − | 53, 61 | True negatived or untargetede | |
| 26 | CIN2 | CIN1 | − | − | − | − | − | True negatived | |
| 48 | CIN2 | CIN1 | − | − | − | − | − | True negatived | |
a
Conducted on the baseline specimen, not the specimen collected at colposcopy; NA, not available.
b
Compared to histology diagnosis.
c
Lesion caused by HPV genotypes not targeted by cobas or AHPV but detected via cross-reactivity by one of the tests.
d
CIN2/3 that may be a misclassified diagnosis.
e
Lesion caused by HPV genotypes not targeted by cobas or AHPV.