TABLE 2.
Cellular profiles of bronchoalveolar lavage fluid in 166 non-HIV-infected patients with Pneumocystis jirovecii pneumoniaa
| Parameter | Values |
P | ||
|---|---|---|---|---|
| All (n = 166) | Mild to moderate (n = 46) | Severe (n = 120) | ||
| Total WBC count (cell/μl), median (IQR) | 180 (80–330) | 230 (130–355) | 180 (80–300) | 0.32 |
| Neutrophil %, median (IQR) | 13.1 (5.3–36.2) | 6.0 (3.4–12.9) | 20.4 (5.8–40.2) | <0.001 |
| Lymphocyte %, median (IQR) | 31.7 (11.8–55.4) | 45.3 (19.9–59.8) | 32.1 (13.0–54.6) | 0.12 |
| Alveolar macrophage %, median (IQR) | 30.2 (18.2–54.2) | 40.7 (22.0–57.1) | 28.3 (15.4–39.8) | 0.01 |
| Neutrophil count (cell/μl), median (IQR) | 22 (6–59) | 13 (4–30) | 24 (7–73) | 0.001 |
| Lymphocyte count (cell/μl), median (IQR) | 44 (12–143) | 68 (29–210) | 49 (8–144) | 0.17 |
| Alveolar macrophage count (cell/μl), median (IQR) | 51 (19–112) | 76 (36–125) | 50 (13–96) | 0.03 |
| Neutrophils dominantb | 38 (22.9) | 3 (6.5) | 35 (29.2) | 0.002 |
| Lymphocytes dominantb | 76 (45.8) | 24 (52.2) | 52 (43.3) | 0.31 |
| Alveolar macrophages dominantb | 52 (31.3) | 19 (41.3) | 33 (27.5) | 0.09 |
| CD4+ T cell %, median (IQR) | 33.4 (23.4–41.3) | 34.4 (23.5–50.8) | 33.0 (23.3–39.8) | 0.21 |
| CD8+ T cell %, median (IQR) | 49.6 (32.1–59.8) | 50.3 (29.4–59.6) | 49.0 (32.7–60.4) | 0.74 |
| CD4+/CD8+ T cell ratio, median (IQR) | 0.7 (0.4–1.1) | 0.7 (0.4–1.5) | 0.7 (0.4–1.0) | 0.74 |
a
Data are no. (%) of patients unless indicated otherwise. WBC, white blood cell; IQR, interquartile range.
b
The most common cell type among bronchoalveolar lavage fluid WBCs.