Table 2.
Antimicrobial activity (IC50s and MICs in µM [mg/mL]) of boric acid and 3–5 against Candida albicans, Staphylococcus aureus, and methicillin resistant S. aureus.
| Compounds | C. albicans | S. aureus | MRSA | |||
|---|---|---|---|---|---|---|
| IC50; SEM1 | MIC2 | IC50; SEM | MIC | IC50; SEM | MIC | |
| B(OH)3 | Inactive3 | Inactive | Inactive | Inactive | Inactive | Inactive |
|
| ||||||
| CAPE (3) | 132.43; 0.40 | 176 | 39.1; 1.10 | 86 | 12.3; 1.50 | 86 |
| [37.65; 0.11] | [50] | [11.12; 0.32] | [25] | [3.5; 0.40] | [25] | |
|
| ||||||
| 4 | 72.2; 0.70 | 125 | 19.93; 1.45 | 42 | 22.9; 1.50 | 84 |
| [43.22; 0.40] | [75] | [11.93; 0.87] | [25] | [13.71; 0.88] | [50] | |
|
| ||||||
| 5 | 146.10; 1.50 | >245 | Inactive | Inactive | 11.35; 1.10 | 61 |
| [119.50; 1.20] | [>200] | [9.28; 0.88] | [50] | |||
1IC50s estimated by probit analysis. 2MIC (minimum inhibitory concentration) is defined as the lowest concentration that showed over 90% inhibition. 3Less than 50% inhibition in initial screening (at 100 μg/mL) is considered to be inactive.