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(A) Hyperactivation of NFκB by p65/RelA overexpression activates CXCR5 promoter in both MCF-7 and MCF-7-2si cells while NFκB inhibition by dominant-negative IκBα results in strong reduction of promoter activity in both cell lines. (B) NFκB reporter construct demonstrates the same pattern of responses to NFκB hyperactivation and inhibition as the CXCR5 promoter. The result of 3 experiments is shown. *P < 0,01.
