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. Author manuscript; available in PMC: 2015 Mar 19.
Published in final edited form as: Sci Transl Med. 2013 Oct 16;5(207):207ra141. doi: 10.1126/scitranslmed.3006479

Fig. 1. TNNI3K is expressed in cardiomyocytes and is up-regulated in human heart failure.

Fig. 1

(A) TNNI3K transcript levels detected across a panel of primary non-pathological human tissue samples. (B) TNNI3K protein level as assessed by Western blot in lysates from whole heart, isolated myocytes, or fibroblasts of the LV; skeletal muscle; peripheral microvascular endothelial cells (PMVECs); lung; or kidney from adult C57BL/6 mice. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) served as a loading control for total protein level. (C) TNNI3K protein level as assessed by Western blot in LV explants from failing hearts of ICM patients undergoing transplant, or nonfailing controls. Data are shown as individual values with means (dashed lines) ± SEM (vertical bars) displayed. *P value determined by Student’s two-tailed t test.