Table 2.
Association of the SLC30A8 genetic polymorphisms with type 2 diabetes and diabetic nephropathy in a Malay population
| SNP ID | Group | N | Genotypes | RAF | P value | Odds ratio | ||
|---|---|---|---|---|---|---|---|---|
| rs13266634 | CC | CT | TT | |||||
| NGT | 438 | 153 | 202 | 83 | 0.580 | 0.053 | 1.200 (0.997 to 1.443) | |
| All T2Da | 506 | 208 | 215 | 83 | 0.620 | |||
| T2D-DN | 236 | 90 | 107 | 39 | 0.608 | 0.098 | 1.313 (0.950 to 1.815) | |
| T2D + DN | 123 | 59 | 47 | 17 | 0.670 | |||
| rs11558471 | AA | AG | GG | |||||
| NGT | 441 | 139 | 209 | 93 | 0.552 | 0.002 | 1.334 (1.110 to 1.602) | |
| All T2Da | 509 | 204 | 225 | 80 | 0.620 | |||
| T2D-DN | 237 | 87 | 107 | 43 | 0.593 | 0.041 | 1.399 (1.013 to 1.932) | |
| T2D + DN | 123 | 57 | 51 | 15 | 0.671 | |||
Tests were conducted with an additive model.
NGT normal glucose tolerance, T2D type 2 diabetes, DN diabetic nephropathy, RAF risk allele frequency.
aThe patients with microalbuminuria were included.