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. 2015 Jan 30;61(3):979–989. doi: 10.1002/hep.27539

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© 2014 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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SRF-VP16-triggered mHCCs share expression profiles with G1/G2 subgroups of hHCCs. (A) Venn diagram depicting differentially expressed transcripts in all three types of tissue (Category I), mHCCs (Category II), nodular tissue (Category III), mHCCs without Ctnnb1 mutation (HCC_A; Category IV), and mHCCs with Ctnnb1 mutation (HCC_B; Category V). (B) Listing of 10 most strongly up- or down-regulated transcripts per category (x-fold differential expression). (C) Cohort of 40 hHCCs grouped according to genomic DLC1 status (X-axis) and SRF mRNA expression levels (Y-axis). IGF2 RNA overexpression status (yellow box), CTNNB1 mutation status (red triangle), Boyault class (G1 and G2, blue arrow; G6, red arrow). (D) Combined unsupervised hierarchical clustering of the 58 most strongly up-regulated transcripts in SRF-VP16-triggered nodular/mHCC tissue against 40-membered hHCC cohort (blue triangles: SRF overexpressing tumors, other symbols as in (C)). The "subcluster of 10" hHCCs (SC10) cluster close to the mHCCs. Murine genes contain a canonical (blue box) or noncanonical CArG-box (blue asterisks).