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. 2015 Jan 30;61(3):979–989. doi: 10.1002/hep.27539

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© 2014 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Genomic methylation profiles of selected sites in murine and human HCCs. (A) Selected transcript expression in SRF-VP16^iHep mice. (B) Genomic CpG methylation ratios (mC/C) at the indicated gene loci of murine tissues. H19 locus investigated at imprinting control region (Igf2/H19 DMR), other genes investigated at promoter. (C) 40-membered hHCC cohort: averaged methylation ratio of CpG sites 1-3 of human IGF2 hP3 promoter blotted versus corresponding hIGF2 mRNA expression levels. Boxed: hHCC subgroup with reduced CpG methylation and concomitantly elevated IGF2 expression. Lower: 5′ regions of the human IGF2 gene (hP0 to hP4 promoters) and the murine Igf2 gene (mP0 to mP3 promoters).