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. 2015 Jan 30;61(3):965–978. doi: 10.1002/hep.27593

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© 2014 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Up-regulation of C/EBPα in human primary HCC tissues predicted poorer patient survival. (A) The C/EBPα protein was determined by immunohistochemical staining in HCC tissue microarrays and is summarized in the right panel. (B) A Kaplan-Meier survival analysis showed that the patients with upregulated C/EBPα had poorer overall survival. (C) The HCC patients were ranked into four different groups according to the difference between C/EBPα expression in tumor (TU) and in nontumor (NT) tissues, with 0 for no difference and 3 for the highest up-regulation. The number of patients analyzed in each group and P values are indicated. (D,E) Kaplan-Meier curves showed the overall survival of HCC patients subgrouped by C/EBPα and serum AFP level (D) or C/EBPα and vascular invasion (E). Disc, discordant risk assessments: high C/EBPα expression and low risk predicted by AFP (<300 ng/mL)/vascular invasion or vice versa. Abbreviations: HBV, hepatitis B virus; HCV, hepatitis C virus.