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. 2015 Mar 19;9:94. doi: 10.3389/fncel.2015.00094

Figure 4.

Figure 4

Shank3Δ9mice do not show autistic-like behavior. (A, B) Shank3Δ9 mice (2–4 months) show normal exploration of a stranger mouse (S1) vs. an inanimate object (O) in the three-chamber social interaction test, as shown by time spent in exploration (A) and social preference index (B). N = 23 (WT), 19 (Shank3Δ9). (C, D) WT and Shank3Δ9 mice show similar preference toward a novel mouse (S2) over a familiar mouse (S1) in the three-chamber social interaction test. N = 8 (WT), 10 (Shank3Δ9), as shown by time spent in exploration (C) and social preference index (D). (E) Shank3Δ9 pups (P4–10) emit normal numbers of USVs when separated from their mother, compared with WT mice. N = 11 (WT), 9 (Shank3Δ9). (F) Shank3Δ9 mice do not show repetitive behaviors except for a small increase in rearing, as determined by behavioral monitoring for three consecutive days with normal light-dark cycles. N = 9 (WT), 11 (Shank3Δ9). *P < 0.05, **P < 0.01, ***P < 0.001, ns, not significant, Student's t-test. Data represent mean ± standard error.