Figure 5.

Shank3^Δ9 mice show increased rearing but normal locomotion in a novel environment. (A) Shank3^Δ9 mice (2–4 months) show increased rearing on day 1 but not on days 2 or 3, as determined by 72-h consecutive monitoring of behavior. (B) During day 1, increased rearing was stronger during the first 2 h in a novel home-cage–like environment. (C) Shank3^Δ9 mice show locomotor activities comparable to those of WT mice during light-off periods on days 1, 2, and 3. (D, E) Shank3^Δ9 mice show normal levels of locomotor activities, as measured by 72-h consecutive monitoring of behavior. It should be noted that Shank3^Δ9 mice tended to be hyperactive during the first 2 h on day 1, but were hypoactive during the rest of day 1 and two following days (days 2 and 3) (D), as is also evident from locomotor activities averaged over all 3 days (E). (F, G) Shank3^Δ9 mice (2–4 months) show normal locomotion in the open field test (F) and normal time spent in the center region of the open field arena compared with WT mice (G). ^*P < 0.05, ^**P < 0.01, ns, not significant, Student's t-test (A, C, G), Two-Way repeated measures ANOVA (B–F). Data represent mean ± standard error.