Figure 6.

Shank3^Δ9mice show mildly impaired spatial memory. (A) Shank3^Δ9 mice (2–4 months) perform normally in the learning and reversal-learning phases of the Morris water maze test, as measured by time taken to escape to platforms. N = 12 (WT), 15 (Shank3^Δ9). Not significant at all-time points (not indicated), Two-Way repeated measures ANOVA. (B, C) Shank3^Δ9 mice show normal quadrant occupancy (B) but decreased number of crossings over the platform location (C) during the probe phase of the Morris water maze test. N = 12 (WT), 15 (Shank3^Δ9). (D) Swim speeds in the Morris water maze were similar between genotypes. N = 12 (WT), 15 (Shank3^Δ9). (E–G) Shank3^Δ9 mice (2–4 months) show normal novel-object preference in the novel object recognition test (E), although total time spent exploring the objects was reduced (F); total locomotion during the test phase was unaltered (G). N = 12 (WT), 15 (Shank3^Δ9). ^*P < 0.05, ns, not significant, Student's t-test. Data represent mean ± standard error.