Table 2.
Summary of the behavioral results in Shank3Δ9 mice.
Behavior category | Assay | Result |
---|---|---|
Social behavior | Three-chamber social interaction (object vs. stranger 1) | Normal |
Social novelty recognition | Three-chamber social interaction (stranger 1 vs. stranger 2) | Normal |
Social communication | Separation-induced pup ultrasonic vocalization | Normal |
Repetitive behavior | Seventy two-hour behavior monitoring | Normal except a small increase in rearing at the beginning of cage habituation |
Locomotor activity | Seventy two-hour behavior monitoring | Normal |
Open field | Normal | |
Anxiety-like behavior | Open field | Normal |
Spatial learning and memory | Morris water maze | Largely normal, except for a decrease in the number of platform crossing |
Object recognition memory | Novel object recognition | Normal |