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. 2015 Mar 19;9:27. doi: 10.3389/fnana.2015.00027

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Copyright © 2015 Puelles and Rubenstein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain subdivisions in a generalized vertebrate model as conceived by Kappers (1947). Note conservation of the sulcus limitans of His (“sillon limitant”), and the clear concept of the sensory and motor longitudinal brainstem zones plus the floor plate (P.AL; P.BAS; PL.V). These bend uniformly around the cephalic flexure and end at the rostrally placed hypothalamus. The middle and ventral thalamic sulci (S.TH.M; S.TH.VEN) are represented as strictly transversal relative to the longitudinal dimension, which obviously does not end in the telencephalon, but in the hypothalamus. Note the notochordal tip contacting the mamillary pouch.