FIGURE 1.

Cell type specific changes in NE composition. Cell differentiation coincides with changes in chromatin organization and protein composition of the nuclear lamina, nuclear envelope and nuclear pore complex. Photoreceptor rod cells lose expression of LBR and Lamin A leading to an inverted chromatin state with heterochromatin in the nuclear interior. Proteomic analysis of differentiated cells shows cell type specific nuclear envelope composition resulting in unique nucleo-cytoplasmic connections influencing cell morphology; and chromatin-NE interactions facilitating intra-nuclear genome reorganization and regulation of gene expression programs. Differentiated muscle cells uniquely express gp210 at the NPC leading to activation of muscle specific genes.