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. 2015 Mar 19;6:38. doi: 10.3389/fendo.2015.00038

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Copyright © 2015 Gao, Chen, Sullivan, Hui, Ouellet, Henderson and Saran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Radiographic evidence of progressive scoliosis in FGFR3^−/− mice: high resolution radiographs were taken of anesthetized mice at monthly intervals up to 4 months of age. Serial radiographs of representative mice shows no evidence of spine curvature in the FGFR3^+/+ animal (upper) at any time point. The FGFR3^−/− animal (lower) shows little evidence of deformity at 1 month, compared with the sigmoid curve that is evident at 2 months, and increases in severity to 4 months.