Skip to main content
. 2015 Mar 19;6:38. doi: 10.3389/fendo.2015.00038

Figure 3.

Figure 3

PTHrP-1-34 inhibits rotation of apical vertebra in FGFR3−/− mice: An X-ray of the intact spine of an FGFR3−/− mouse captured by micro CT (A), is shown adjacent to the mid-region 2D CT images of the identified vertebrae (B). The L5 image was aligned in the horizontal axis (dotted line) as a reference point to measure the degree of axial rotation (arrows) on T8, T10, and T12. 3D reconstruction of the lower thoracic spine of FGFR3+/+ (C) and FGFR3−/− (D,E) mice revealed an overall reduction in axial rotation of the vertebrae in FGFR3−/− mice treated with PTHrP-1-34 (C, N = 16) compared with mice treated with placebo [(B), N = 18]. Quantitative analysis of axial rotation of the apical vertebra in placebo (white) and PTHrP-1-34 (gray) treated mice is shown in the bar graph (F).