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. 2015 Mar 19;8:9. doi: 10.3389/fnmol.2015.00009

Figure 6.

Figure 6

A possible network of interactions between proteins and RNAs, at the basis of FrontoTemporal Dementia. Green arrows indicate binding interactions or processes that result in activation or increased expression. Red arrows indicate binding interactions or processes that result in inhibition of activity or reduced expression. Black arrows indicate binding interactions or processes whose result can be either positive or negative. Purple arrows indicate binding interactions or processes which are hypotetical. Symbols as in Legend. lncRNAs, long non-coding RNA; TDP-43, TAR DNA binding protein; FUS, Fused in Sarcoma; GRN, progranulin; MAPT, Microtubule-Associated Protein Tau; VCP, Valosin Containing Protein; C9ORF72. CHMP2B, Charged multivesicular body protein 2b; Rab7, Ras-related protein 7.