Table 2.
Changes in disability and walking capacity in TIMER
| Baseline (N = 215) | Week 24 (n = 207) | Week 48 (n = 199) | |
|---|---|---|---|
| EDSS score | |||
| Mean (SD) | 3.7 (1.36) | 3.6 (1.37)a | 3.5 (1.39)a |
| Median (range) | 4.0 (2.5–5.0) | 4.0 (2.0–4.5) | 4.0 (2.0–4.5) |
| T25FW, s | |||
| Mean (SD) | 9.0 (6.76) | 8.9 (6.66) | 8.9 (6.43) |
| Median (range) | 6.6 (3.2–53.2) | 6.6 (3.2–54.1) | 6.5 (3.2–45.0) |
| T25FW speed, m/s | |||
| Mean (SD) | 1.11 (0.47) | 1.14 (0.49)b | 1.14 (0.48)c |
| Median (range) | 1.16 (0.14–2.38) | 1.16 (0.14–2.38) | 1.18 (0.17–2.38) |
| T100MW, s | |||
| Mean (SD) | 112.5 (83.02) | 108.2 (87.46) | 106.2 (85.22) |
| Median (range) | 86.0 (30.7–636.0) | 83.1 (31.2–750.0) | 83.2 (31.7–718.0) |
| T100MW speed, m/s | |||
| Mean (SD) | 1.19 (0.55) | 1.27 (0.58)a | 1.29 (0.59)d |
| Median (range) | 1.16 (0.16–3.26) | 1.20 (0.13–3.21) | 1.20 (0.14–3.16) |
| MWD, m | |||
| Mean (SD) | 651.9 (691.63)e | 674.5 (665.17)f | 701.2 (739.63)g |
| Median (range) | 350.0 (10.0–3000.0)e | 400.0 (20.0–3000.0)f | 450.0 (20.0–3500.0)g |
EDSS, Expanded Disability Status Scale; T25FW, timed 25-foot walk; T100MW, timed 100-m walk; MWD, maximum walking distance. aP < 0.0001 vs. baseline; bP = 0.0074 vs. baseline; cP = 0.1643 vs. baseline; dP = 0.0001 vs. baseline; en = 143; fn = 136; gn = 129.