Table 2.
Odds ratio (OR) with 95% confidence interval (CI) of developing multiple sclerosis for subjects with a reported history of infectious mononucleosis, based on EIMS and GEMS data, and limited to HLA-DRB1*15 negative subjects in EIMS
| EIMS ca/coa |
OR (95% CI) c | OR (95% CI) d | P | ca/cob | OR (95% CI) e | GEMS ca/coa |
OR (95% CI)b | P | |
|---|---|---|---|---|---|---|---|---|---|
| Total | 326/421 | 1.9 (1.6–2.2) | 1.9 (1.6–2.3) | <0.0001 | 172/361 | 1.9 (1.6–2.3) | 615/314 | 1.9 (1.6–2.2) | <0.0001 |
| Women | 246/322 | 1.8 (1.5–2.2) | 1.9 (1.5–2.4) | <0.0001 | 126/275 | 1.8 (1.5–2.3) | 472/254 | 1.8 (1.6–2.2) | <0.0001 |
| Men | 80/99 | 1.9 (1.4–2.7) | 2.0 (1.3–3.1) | <0.0001 | 46/86 | 2.2 (1.5–3.3) | 143/60 | 2.1 (1.6–2.9) | <0.0001 |
| BMI < 27 | 289/407 | 1.8 (1.5–2.1) | 1.8 (1.4–2.2) | <0.0001 | 149/347 | 1.8 (1.4–2.2) | 574/307 | 1.8 (1.6–2.1) | <0.0001 |
| BMI > 27 | 37/14 | 3.7 (1.9–7.3) | 6.9 (2.4–19.8) | 0.0002 | 23/14 | 4.1 (1.9–9.1) | 41/7 | 4.1 (1.8–9.3) | 0.0009 |
BMI, body mass index.
aNumber of exposed cases and controls. bAdjusted for matching variables, origin, smoking habits, HLA-DRB1*15 and HLA-A*02. cNumber of HLA-DRB1*15 negative cases and controls. dAdjusted for matching variables, origin and smoking habits. eAdjusted for matching variables, origin, smoking habits and HLA-A*02.