Table 3.
BMI > 27 | IM | ca/coa | OR (95% CI)b | OR (95% CI)c | P |
---|---|---|---|---|---|
EIMS | Past IM | ||||
− | − | 1325/3277 | 1.0 (–) | 1.0 (–) | |
+ | − | 129/187 | 1.7 (1.3–2.1) | 1.7 (1.4–2.2) | <0.0001 |
− | + | 289/407 | 1.8 (1.5–2.1) | 1.8 (1.5–2.2) | <0.0001 |
+ | + | 37/14 | 6.6 (3.6–12.4) | 8.1 (4.2–15.0) | <0.0001 |
Interaction term | 2.2 (1.1–4.4) | 2.6 (1.3–5.2) | 0.009 | ||
AP | 0.6 (0.2–0.8) | 0.7 (0.3–0.8) | |||
RERI | 4.2 (1.1–9.9) | 5.5 (1.7–12.8) | |||
SI | 3.9 (1.7–8.6) | 4.6 (2.0–10.2) | |||
IM after age 10 | |||||
− | − | 1325/3277 | 1.0 (–) | 1.0 (–) | |
+ | − | 129/187 | 1.7 (1.3–2.1) | 1.7 (1.4–2.2) | <0.0001 |
− | + | 208/249 | 2.1 (1.7–2.6) | 2.1 (1.7–2.6) | <0.0001 |
+ | + | 28/6 | 12.0 (4.9–29.1) | 14.7 (5.9–36.6) | <0.0001 |
Interaction term | 3.4 (1.3–8.6) | 4.0 (1.5–10.4) | 0.005 | ||
AP | 0.8 (0.4–0.8) | 0.8 (0.4–0.9) | |||
RERI | 9.2 (2.1–26.3) | 11.9 (3.1–33.7) | |||
SI | 6.2 (2.2–17.0) | 7.4 (2.6–20.6) | |||
GEMS | Past IM | ||||
− | − | 3644/3574 | 1.0 (–) | ||
+ | − | 196/152 | 1.3 (1.0–1.6) | <0.0001 | |
− | + | 618/306 | 2.0 (1.7–2.3) | 0.002 | |
+ | + | 44/7 | 6.3 (2.8–13.9) | <0.0001 | |
Interaction termd | 2.4 (1.1–5.6) | 0.04 | |||
AP | 0.7 (0.2–0.8) | ||||
RERI | 5.5 (1.2–16.7) | ||||
SI | 4.6 (2.0–10.2) | ||||
IM after age 10 | |||||
− | − | 3644/3574 | 1.0 (–) | ||
+ | − | 196/152 | 1.3 (1.0–1.6) | 0.03 | |
− | + | 505/245 | 1.8 (1.8–2.4) | <0.0001 | |
+ | + | 37/4 | 9.3 (3.3–26.1) | <0.0001 | |
Interaction term | 3.5 (1.2–10.2) | 0.02 | |||
AP | 0.7 (0.09–0.8) | ||||
RERI | 6.9 (0.8–27.2) | ||||
SI | 6.2 (1.9–20.4) |
aNumber of exposed cases and controls; badjusted for matching variables, origin and smoking habits; cadjusted for matching variables, origin, smoking habits, HLA-DRB1*15 and HLA-A*02; dindicates interaction on the multiplicative scale.