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. Author manuscript; available in PMC: 2015 Mar 19.
Published in final edited form as: Int J Cancer. 2013 Nov 18;134(10):2322–2329. doi: 10.1002/ijc.28579

Figure 3.

Figure 3

MLN0128 was superior to temsirolimus in inhibiting metastases. mRCC cells were observed surrounding blood vessels (arrows in a–c) in livers of mice carrying TSG cohort 3. They expressed Ku70 (a), a human-specific nuclear antigen, CAIX (b) and were negative for CD10 (c). MLN0128 but not temsirolimus reduced the mean ratio of mRCC cells vs. total cells, measured as the ratio of human-specific GAPDH to total GAPDH by qRT-PCR (d). The effects were statistically significant as shown by p-values of Student’s t-test (e). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]