Table 2.
Comparison of Hormonal Responses to Dextrose and Lipid Infusions in Healthy Controls vs Dyspepsia Patients
| Patient Groupa | ||||
|---|---|---|---|---|
| Hormone | Controls | Patients | ||
| Dextrose Infusion | Lipid Infusion | Dextrose Infusion | Lipid Infusion | |
| Glucose | 19,455 (17,880–22,885) P<.001b |
11,663 (11,304–12,518) |
23,363 (19,650–27,988) P≤.03c |
11,429 (10,810–12,446) |
| C-peptide | 381 (271–534)P<.001b | 85 (67–121) | 566 (258–821) | 145 (88–299) P≤.01c |
| Glucagon | 2,776 (2,226–3,244) P=.02b |
3,300 (2,603–3,963) |
3,125 (2,514–3,862) |
3,773 (2,847–5,071) |
| GIP | 6,010 (5,040–8,232) P<.001b |
2,933 (2,279–4,392) |
6,369 (5,158–8,005) |
4,118 (3,241–6,553)P≤.03c |
| GLP1 | 2,534 (1,243–3,331) |
1,768 (1,063–2,909) |
2,857 (1,826–3,586) |
2,840 (1,740–3,930) P≤.03c |
| CCK | 430 (296–602) | 926 (619–1,130) | 465 (279–618) | 804 (571–1087) |
| Ghrelin | 68,255 (62,400–76,103) |
83,930 (71,508–95,208) |
72,123 (57,835–82,475) |
78,808 (69,323–87,563) |
| PYY | 5,400 (3,988–7,311) |
5,406 (3,733–6,500) |
4,773 (3,746–6,155) |
5,963 (4,817–7,577) |
Abbreviations: CCK, cholecystokinin; GIP, glucose-dependent insulinotropic peptide; GLP1, glucagonlike peptide 1; IGT, impaired glucose intolerance; NGT, normal glucose tolerance; PYY, protein YY.
a
Values are presented (area under the curve) as pmol/L per min (CCK, glucagon, GIP, GLP1, and PYY), mg/dL per min (glucose), pg/mL per min (ghrelin) and as nmol/L (C-peptide)
b
vs lipids in controls
c
vs corresponding nutrient, controls