Table 3.
Comparison of Hormonal Responses to Dextrose and Lipid Infusions in Healthy Controls vs Dyspepsia Patients With NGT or IGT
| Hormone | NGT (n=16) | IGT (n=8) | ||
|---|---|---|---|---|
| Dextrose Infusion | Lipid Infusion | Dextrose Infusion | Lipid Infusion | |
| Glucose | 20,450 (19,530–23,110) |
11,184 (10,464–11,933) |
29,491 (28,151–31,774) P≤.004a |
12,278 (11,221–14,001) |
| C-peptide | 559 (172–800) |
145 (88–305) |
611 (497–837) |
105 (85–244) |
| Glucagon | 2,623 (2,257–4,079) |
3,379 (2,817–5,527) |
3,374 (3,032–3,687) |
4,151 (3,148–4,767) |
| GIP | 5,916 (4,807–7,304) |
3,900 (3,034–5,980) |
6,810 (5,959–10,327) |
5,392 (3,998–8,187) |
| GLP1 | 2,298 (1,721–3,312) |
2,658 (1,250–3,466) |
3,811 (3,353–4,953) P≤.004a |
3,248 (2,363–4,351) |
| CCK | 459 (255–618) | 652 (507–1,019) | 519 (335–612) | 940 (790–1,106) |
| Ghrelin | 67,260 (57,835–82,475) | 79,248 (73,053– 90,054) |
72,765 (51,208– 81,203) |
71,379 (63,698– 84,026) |
| PYY | 4,090 (3,622–5,552) |
5,502 (4,095–6,897) |
6,645 (5,451–7,836) P=.01a |
7,577 (6,580–9,008)P=.01a |
Abbreviations: CCK, cholecystokinin; GIP, glucose-dependent insulinotropic peptide; GLP1, glucagonlike peptide 1; IGT, impaired glucose intolerance; NGT, normal glucose tolerance; PYY, protein YY.
Values are presented (area under the curve) as pmol/L per min (CCK, glucagon, GIP, GLP1, and PYY), mg/dL per min (glucose), pg/mL per min (ghrelin) and as nmol/L (C-peptide)
a
P values are vs corresponding nutrient, NGT.