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. 2015 Mar 18;15:143. doi: 10.1186/s12885-015-1159-3

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© Keller et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Area-density segmentations on right, mediolateral-oblique view mammograms for various SNP genotypes. Four Caucasian women with negative screening exams and different genotypes of rs3817198 in LSP1 (a,b) and rs1045485 in CASP8 (c,d). Mammograms in the left column (a,c) represent women who are homozygous for the common allele for each SNP, while mammograms in the right column (b,d) are from women who are homozygous for the risk allele for each SNP. Overall, SNPs, age, Gail life-time risk and BMI were found to only explain a small fraction of the variability in breast density between women. For reference, each woman’s age and overall PD% score are provided as annotations on each image.