Table 3.
Regression analysis between number of SNP risk alleles and log-transformed absolute (top) and relative percent (bottom) area density measures in Caucasian (left) and African-American (right) women for each of the 12 SNPs evaluated in this study, after adjusting for age, BMI and Gail lifetime risk
| Absolute area density | ||||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Caucasian women (N = 389) | African-American women (N = 250) | ||||||
| B | p-value | [95% CI] | B | p-value | [95% CI] | |||
| rs1045485 | 0.002 | 0.919 | −0.041 | 0.045 | −0.014 | 0.717 | −0.088 | 0.060 |
| rs11249433 | −0.014 | 0.367 | −0.045 | 0.017 | −0.016 | 0.540 | −0.065 | 0.034 |
| rs1219648 | −0.014 | 0.375 | −0.046 | 0.017 | 0.021 | 0.300 | −0.019 | 0.061 |
| rs13281615 | 0.001 | 0.970 | −0.029 | 0.030 | −0.018 | 0.363 | −0.055 | 0.020 |
| rs13387042 | 0.014 | 0.353 | −0.015 | 0.043 | 0.008 | 0.679 | −0.031 | 0.048 |
| rs3803662 | 0.017 | 0.309 | −0.016 | 0.050 | 0.024 | 0.219 | −0.014 | 0.062 |
| rs3817198 | −0.047 | 0.004 | −0.080 | −0.015 | 0.032 | 0.175 | −0.014 | 0.079 |
| rs4415084 | 0.021 | 0.182 | −0.010 | 0.053 | −0.003 | 0.876 | −0.039 | 0.034 |
| rs4973768 | −0.005 | 0.760 | −0.035 | 0.026 | −0.035 | 0.080 | −0.074 | 0.004 |
| rs6504950 | 0.008 | 0.650 | −0.027 | 0.043 | −0.009 | 0.633 | −0.046 | 0.028 |
| rs889312 | −0.022 | 0.194 | −0.056 | 0.011 | 0.003 | 0.873 | −0.037 | 0.043 |
| rs999737 | −0.020 | 0.280 | −0.057 | 0.016 | −0.050 | 0.262 | −0.137 | 0.037 |
| Area percent density (PD%) | ||||||||
| SNP | Caucasian women (N = 389) | African-American women (N = 250) | ||||||
| B | p-value | [95% CI] | B | p-value | [95% CI] | |||
| rs1045485 | −0.002 | 0.934 | −0.049 | 0.045 | −0.022 | 0.626 | −0.112 | 0.067 |
| rs11249433 | −0.007 | 0.674 | −0.040 | 0.026 | −0.027 | 0.370 | −0.087 | 0.032 |
| rs1219648 | −0.011 | 0.524 | −0.045 | 0.023 | 0.008 | 0.760 | −0.041 | 0.056 |
| rs13281615 | −0.014 | 0.382 | −0.046 | 0.018 | 0.010 | 0.659 | −0.035 | 0.056 |
| rs13387042 | 0.025 | 0.117 | −0.006 | 0.056 | 0.004 | 0.878 | −0.045 | 0.052 |
| rs3803662 | 0.020 | 0.269 | −0.015 | 0.055 | 0.004 | 0.866 | −0.042 | 0.050 |
| rs3817198 | −0.033 | 0.061 | −0.068 | 0.002 | 0.046 | 0.108 | −0.010 | 0.103 |
| rs4415084 | 0.025 | 0.149 | −0.009 | 0.059 | 0.006 | 0.776 | −0.038 | 0.051 |
| rs4973768 | 0.015 | 0.388 | −0.018 | 0.048 | −0.029 | 0.239 | −0.077 | 0.019 |
| rs6504950 | 0.013 | 0.504 | −0.025 | 0.050 | −0.007 | 0.768 | −0.051 | 0.037 |
| rs889312 | −0.017 | 0.352 | −0.053 | 0.019 | −0.012 | 0.621 | −0.061 | 0.036 |
| rs999737 | −0.015 | 0.461 | −0.054 | 0.025 | −0.038 | 0.480 | −0.142 | 0.067 |
The regression coefficient estimate for each individual SNP (B), p-values and the 95% confidence interval of the regression coefficients ([95% CI]) are provided. Significant associations are italicized and bolded.