Table 4.
Regression analysis between number of SNP risk alleles and log-transformed absolute (top) and relative percent (bottom) fibroglandular tissue volume in Caucasian (left) and African-American (right) women for each of the 12 SNPs evaluated in this study, after adjusting for age, BMI and Gail lifetime risk
| Absolute volume density | ||||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Caucasian women (N = 389) | African-American women (N = 250) | ||||||
| B | p-value | [95% CI] | B | p-value | [95% CI] | |||
| rs1045485 | 0.011 | 0.658 | −0.039 | 0.061 | −0.005 | 0.923 | −0.097 | 0.088 |
| rs11249433 | 0.015 | 0.399 | −0.020 | 0.051 | 0.005 | 0.879 | −0.057 | 0.066 |
| rs1219648 | −0.016 | 0.398 | −0.052 | 0.021 | 0.004 | 0.886 | −0.046 | 0.054 |
| rs13281615 | 0.007 | 0.706 | −0.027 | 0.041 | −0.043 | 0.071 | −0.090 | 0.004 |
| rs13387042 | 0.001 | 0.941 | −0.032 | 0.035 | 0.003 | 0.913 | −0.047 | 0.053 |
| rs3803662 | 0.010 | 0.599 | −0.028 | 0.048 | 0.049 | 0.043 | 0.002 | 0.097 |
| rs3817198 | −0.045 | 0.019 | −0.082 | −0.007 | 0.008 | 0.792 | −0.051 | 0.067 |
| rs4415084 | 0.011 | 0.567 | −0.026 | 0.047 | 0.020 | 0.383 | −0.025 | 0.066 |
| rs4973768 | −0.033 | 0.070 | −0.068 | 0.003 | −0.035 | 0.161 | −0.085 | 0.014 |
| rs6504950 | 0.008 | 0.693 | −0.032 | 0.048 | 0.001 | 0.964 | −0.044 | 0.047 |
| rs889312 | −0.015 | 0.455 | −0.054 | 0.024 | 0.027 | 0.285 | −0.023 | 0.077 |
| rs999737 | −0.006 | 0.797 | −0.048 | 0.037 | −0.075 | 0.176 | −0.182 | 0.033 |
| Volume percent density (VD%) | ||||||||
| SNP | Caucasian women (N = 389) | African-American women (N = 250) | ||||||
| B | p-value | [95% CI] | B | p-value | [95% CI] | |||
| rs1045485 | −0.002 | 0.907 | −0.036 | 0.032 | −0.021 | 0.492 | −0.081 | 0.039 |
| rs11249433 | 0.017 | 0.167 | −0.007 | 0.041 | −0.021 | 0.309 | −0.061 | 0.019 |
| rs1219648 | −0.016 | 0.210 | −0.041 | 0.009 | −0.017 | 0.317 | −0.049 | 0.016 |
| rs13281615 | −0.014 | 0.251 | −0.037 | 0.010 | 0.011 | 0.490 | −0.020 | 0.041 |
| rs13387042 | 0.021 | 0.072 | −0.002 | 0.044 | 0.008 | 0.633 | −0.025 | 0.040 |
| rs3803662 | 0.008 | 0.522 | −0.017 | 0.034 | 0.020 | 0.200 | −0.011 | 0.051 |
| rs3817198 | −0.023 | 0.076 | −0.048 | 0.002 | 0.023 | 0.229 | −0.015 | 0.062 |
| rs4415084 | 0.017 | 0.179 | −0.008 | 0.041 | 0.029 | 0.057 | −0.001 | 0.058 |
| rs4973768 | −0.005 | 0.680 | −0.029 | 0.019 | −0.036 | 0.028 | −0.068 | −0.004 |
| rs6504950 | 0.005 | 0.698 | −0.022 | 0.032 | 0.011 | 0.483 | −0.019 | 0.040 |
| rs889312 | −0.012 | 0.386 | −0.038 | 0.015 | 0.001 | 0.971 | −0.032 | 0.033 |
| rs999737 | 0.000 | 0.984 | −0.029 | 0.028 | −0.058 | 0.109 | −0.128 | 0.013 |
The regression coefficient estimate for each individual SNP (B), p-values and the 95% confidence interval of the regression coefficients ([95% CI]) are provided. Significant associations are italicized and bolded.