Table 3.
Parameters of systemic inflammation during pulmonary TB
| Controls n = 29 | TB n = 54 | |
|---|---|---|
| IL-6 (pg/mL) | 0.3 (0.06-0.7) | 5.8 (3.3-12)*** |
| IL-8 (pg/mL) | 0.8 (0.4-1.4) | 2.2 (1.3-3.7)*** |
| IP-10 (ng/mL) | 0.37 (0.3-0.46) | 2.8 (1.6-3.7)*** |
| sIL-2Rα (pg/mL) | 74 (54–101) | 225 (152–349)*** |
| sICAM-1 (ng/mL) | 170 (145–214) | 344 (279–418)*** |
| sTNFR-1 (ng/mL) | 0.9 (0.7-1.0) | 1.7 (1.1-2.0)*** |
| sTNFR-2 (ng/mL) | 5.1 (4.6-6.0) | 10 (7.8-13)*** |
| CRP (μg/mL) | 0.9 (0.3-2.6) | 51 (23–90)*** |
Abbreviations: IL interleukin; IP-10 Interferon gamma-induced protein (CXCL) 10; sIL-2Rα soluble interleukin-2 receptor α; sICAM-1 soluble intercellular adhesion molecule-1; sTNFR-1,-2 soluble tumour necrosis factor receptor-1 and −2; sST2 soluble ST2 (IL1R like 1); CRP C-reactive protein. Data are medians with interquartile ranges. ***P < 0.001 for the difference between primary TB versus controls. Depicted are medians with interquartile ranges.