Table 3.

Sensitivity analyses for early pregnancy exposure to hormonal contraceptives and offspring overweight or obesity

		n	OR (95% CI)	Adjusted** OR (95% CI)
Approach 1: Compared to former users Combination OC
former* user of Combination OC		6,146	referent	referent
*early pregnancy Combination OC user		380	0.76 (0.54, 1.07)	0.75 (0.52, 1.06)
Progestin only OC
former* user of Progestin OC		1,962	referent	referent
*early pregnancy Progestin OC user		127	1.20 (0.74, 1.94)	1.24 (0.75, 2.04)
Approach 2: Compared to unplanned pregnancies
No hormonal contraception†		2,264	referent	referent
Combination OC		380	0.67 (0.46, 0.96)	0.70 (0.48, 1.02)
Progestin only OC		127	1.19 (0.73, 1.93)	1.22 (0.75, 1.98)
Other‡		60	0.79 (0.36, 1.76)	0.79 (0.35, 1.78)
Approach 3: Compared to other oral hormonal contraceptive users
Progestin only OC		127	referent	referent
Combination OC		380	0.46 (0.23, 0.91)	0.56 (0.32, 1.00)

^*former use defined as within 12 months but not within 4 months of conception and early defined as within 12 weeks of conception

^**adjusted for maternal age, maternal smoking at 17 weeks gestation, maternal pre-pregnancy BMI, education, and parity

^†no use of a hormonal contraceptive within 12 months before conception and 12 weeks after conception

^‡hormonal contraceptives with < 10 exposed cases were combined into an “other” category