Values predicted from general linear model of ADAS-Cog score, representing global cognitive impairment, regressed on diagnostic group and number of APOE4 alleles. The lines indicate the predicted values for ADAS-Cog and the symbols denote corresponding actual values. AD (Alzheimer’s disease), ADAS-Cog (Alzheimer Disease Assessment Scale Cognitive Subscale), APOE4 (Apolipoprotein E ε4), MCI (mild cognitive impairment), NC (normal older control).