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. 2015 Mar 19;10(3):e0116096. doi: 10.1371/journal.pone.0116096

Table 1. Genes in Tsc1 null MEFs scoring positive in 2 or more replicates.

Gene Symbol GeneID Functional Class
Tagln3 56370 cytoskeleton-actin binding
Myl7 17898 cytoskeleton-myosin light chain
Myo3b 329421 cytoskeleton-non-muscle myosin
Tekt2 24084 cytoskeleton-spindle assembly
Tuba3 22144 cytoskeleton-tubulin
Dncic1 13426 cytroskeleton-Dynein subunit
Actl6b 83766 DNA modif-transcription-chromatin remodeling
Fen1 14156 DNA modification-flap structure-specific endonuclease 1
Smarcal1 54380 DNA modification-SWI/SNF related matrix associated, actin dependent chromatin regulator
Dnttip1 76233 DNA modification-terminal transferase interacting protein
Top3b 21976 DNA modification-topoisomerase 3
Wrn 22427 DNA modifocation-helicase
Shfm1 20422 DNA repair via BRCA2; also protein modification and RNA export
Ddb1 13194 DNA repair; protein ubiquitination
Mcm5 17218 DNA replication
Gpr1 241070 GPCR-chemerin
Ccr3 12771 GPCR-chemokine receptor
Gpr23 78134 GPCR-Lysophosphatidic acid
Olfr410 258702 GPCR-olf
Oxtr 18430 GPCR-oxytocin
Ffar3 233080 GPCR-short chain fatty acids
Gpr3 14748 GPCR-sphingosine 1-phosphate
Sphk1 20698 intracellualr signaling-sphingosine-1 kinase
Strada 72149 intracellular signaling- AMPK cofactor; STE20-related kinase adapter protein alpha
Pla2g2e 26970 intracellular signaling- Phospholipase A variant
Limd2 67803 intracellular signaling-binds protein kinase ILK
Edaradd 171211 intracellular signaling-EDAR associated protein
Gnefr 27414 intracellular signaling-exocyst-secretion regulating guanine nucleotide exchange factor
Rgl2 19732 intracellular signaling-guanyl nucleotide exchanger for Ral GTPases
Pla2g3 237625 intracellular signaling-Phospholipase A variant
Bmp8a 12163 ligand-
Uvrag1 78610 membrane traffic-activates the Beclin1-PI(3)KC3 complex to promote autophagy
Rab3a 19339 membrane traffic-Rab GTPase
Tmem38b 52076 membrane transport—TRIC-B cation channel
Grik5 14809 membrane transport-ionotropic glutamate receptor
Atp6v1c1 66335 membrane transport-v-ATPase subunit
Atp6v1h 108664 membrane transport-v-ATPase subunit
Mfsd10 68294 membrane-transport-major facilitator superfamily domain-containing protein 10
Cel 12613 metabolism-carboxyl ester(lipid) esterase
Fabp4 11770 metabolism-fatty acid binding
Ugcg 22234 metabolism-UDP-glucose ceramide glucosyltransferase
Slc25a24 229731 mitochondria-calcium dependent ATP-Mg2 uptake to buffer mito calcium
Gtpbp8 66067 mitochondria-GTP-binding protein 8, Gtpbp8
Mut 17850 mitochondria-methylmalonyl CoA mutase
Pcca 110821 mitochondria-propionyl CoA carboxylase, alpha
Pdhx 27402 mitochondria-pyruvate dehydrogenase complex, component X
Uqcr10 66152 mitochondria-ubiquinol-cytochrome c reductase, complex III subunit
Mtor 56717 protein kinase
Capn3 12335 protein modification-calpain 3
Casp1 12362 protein modification-caspase 1
Mmp11 17385 protein modification-matrix metalloproteinase
Mmp12 17381 protein modification-matrix metalloproteinase
Adamts1 11504 Protein modification-matrix metalloproteinase like
Serpinb5 20724 protein modification-serine (or cysteine) peptidase inhibitor, clade B, member 5
Ube2k 53323 protein modification-ubiquitin-conjugating enzyme
Tnpo2 212999 protein traffic-cytoplamic nuclear transport
Tmem115 56395 receptor
Tmem121 69195 receptor
Cd19 12478 receptor-B cell Ag coreceptor
Fcgr4 246256 receptor-FC
Ifitm1 68713 receptor-interferon induced transmembrane protein 1
Cd163 93671 receptor-scavenger family
Rps24 20088 RNA-40S ribsosomal subunit
Nob1 67619 RNA-ribosome assembly
Ints7 77065 RNA-snRNA biogenesis
Urm1 68205 RNA-tRNA sulfuration-ubiquitin related modifier 1 homolog
U2af1 108121 RNA-U2 small nuclear ribonucleoprotein auxiliary factor
Yipf2 74766 transcription
Zfp524 66056 transcription factor
Batf2 74481 transcription-ATF2-like
Ccnk 12454 Transcription-cyclin K-RNA polymerase CTD kinases
Rax 19434 transcription-homeobox protein
Trp53bp2 209456 transcription-proapoptotic tumor suppressor ASPP2
Thoc7 66231 transcription-RNA export
Ssu72 68991 transcription-RNA polymerase II subunit A C-terminal domain phosphatase
Lypd1 72585 unknown-? Tumor suppressor