Fig 1. Segmentation of the regions of interest (ROI) CE-T1 tumor and T2 peritumoral edema.
Glioblastoma of the left temporal lobe in patient 6. Coregistered images from the different sequences showing an exemplary slice of the whole tumor volume for this patient. A) CE-T1 tumor ROI (red line) segmented on CE T1-weighted image while thoroughly excluding central necrosis. B) T2 peritumoral edema ROI (green line) segmented on T2-weighted image. C) Coregistered ADC map and D) MTRasym contrast illustrating both ROIs. The glioblastoma tumor and the cerebrospinal fluid in sulci and ventricles display hyperintense on NOE mediated CEST based on MTRasym.