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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neurobiol Aging. 2014 May 9;35(11):2429–2435. doi: 10.1016/j.neurobiolaging.2014.05.002

Table 3.

Association between thiazide and potassium-sparing diuretics and incident AD from Cox proportional hazards model in both the whole sample and anti-HTN users

Drug category Number of users Whole samplea Anti-HTN drug users
aHR (95% CI)b p aHR (95% CI)b p
Thiazide and potassium-sparing diuretics in combination 433 0.63 (0.42–0.94) 0.023 0.69 (0.45–1.06) 0.094
Thiazide without potassium-sparing diuretics 507 0.69 (0.47–1.02) 0.061 0.78 (0.51–1.17) 0.225
Potassium-sparing without thiazide diuretics 43 0.56 (0.18–1.76) 0.322 0.64 (0.20–2.02) 0.443
Other anti-HTN drugs 1054 0.88 (0.67–1.16) 0.364 REF REF

Key: AD, Alzheimer’s disease; aHR, adjusted hazard ratio; CABG, coronary artery bypass graft; CI, confidence interval; MI, myocardial infarction; NA, not applicable; REF, reference group.

a

The reference group is nonusers of anti-HTN drugs.

b

Adjusted relative hazard estimated from models that control for age, sex, education, number of APOE ε4 alleles, smoking and drinking habits at baseline, history of high cholesterol, diabetes, stroke, CABG, and MI.