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. 2015 Mar 19;10(3):e0117074. doi: 10.1371/journal.pone.0117074

Table 7. Enriched cytoskeletal proteins tagged by biotin ligase fused to occludin and claudin-4.

Accession Name Localization/Function-Cytoskeleton OCLN N OCLN C CLD4 N ZO-1 N ZO-1 C E-CAD
345804799 345804801 Brain-specific angiogenesis inhibitor 1-associated protein 2 Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. 18.8 7.4 38.3 ND ND ND
359320122 Fermitin family homolog 2 Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2. 10.6 ND 13.2 ND ND ND
345780352 Septin-7 Filament-forming cytoskeletal GTPase involved in actin cytoskeleton organization. 10.1 7.4 16.3 ND 0.6 ND
345776847 Cdc42 effector protein 1 Organization of the actin cytoskeleton. 7.7 2.8 9.2 ND ND ND
73963313 Pleckstrin-2 Cytoskeletal arrangement and lamellipodia formation. 6.4 ND ND ND ND ND
73950452 MARCKS-related protein Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. 5.5 2.8 27.4 ND ND 3.0
73955372 Profilin-1 Binds to actin and affects the structure of the cytoskeleton. 3.6 5.6 (2.7) 3.0 4.7 (0.6)
345780124 Neurabin-1 Binds to actin filaments and shows cross-linking activity. 3.3 ND 4.9 ND ND ND
73965092 Cdc42 effector protein 4 Organization of the actin cytoskeleton. 2.9 2.5 5.7 ND ND ND
73998521 Gamma-adducin Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. 2.7 2.3 5.5 ND ND ND
345789997 Erythrocyte membrane protein band 4.1-like 1 Major structural element of the erythrocyte membrane skeleton. (2.5) 1.5 4.8 ND ND ND
73969750 EH domain-binding protein 1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. (1.4) 4.0 ND ND ND ND
345799052 PDZ and LIM domain protein 7 Adapter protein that, via its PDZ domain, localizes LIM-binding proteins to actin filaments. ND 24.4 ND ND 12.0 ND
74010709 Drebrin-like Adapter protein that binds F-actin and DNM1, and thereby plays a role in endocytosis. Reorganization of the actin cytoskeleton and formation of cell projections via its interaction with WASL and COBL. ND 7.6 ND ND 12.9 ND
73952670 Ankyrin-3 Membrane-cytoskeleton linker. ND 7.2 ND ND (0.6) 3.8
345794001 Phosphatase and actin regulator 4 Regulator of protein phosphatase 1 (PP1), actin-binding protein. ND 1.7 ND ND ND 2.6
74003992 Tubulin beta-2A chain Tubulin is the major constituent of microtubules. ND ND 9.4 ND 23.0 ND
345801304 BAI1-associated protein 2-like 1 Adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. ND ND 9.2 ND (0.8) ND