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. 2015 Mar 19;10(3):e0117074. doi: 10.1371/journal.pone.0117074

Table 8. Enriched membrane proteins tagged by biotin ligase fused to occludin and claudin-4.

Accession Name Localization/Function-Membrane OCLN N OCLN C CLD4 N ZO-1 N ZO-1 C E-CAD Reference
345794237 Plasmolipin Appears to be involved in myelination. Receptor for McERV. Could also participate in ion transport. 37.9 12.2 35.3 ND ND ND
345807298 SLIT and NTRK-like family, member 4 Slitrks have been implicated in mediating basic neuronal processes, full function unknown. Membrane protein. 29.6 23.3 21.1 4.0 ND 9.1
73998757 Pleckstrin homology domain-containing family A member 1 Binds specifically to phosphatidylinositol 3,4-diphosphate. May recruit other proteins to the plasma membrane. 26.0 ND ND ND ND 2.8
114326335 Palmitoyltransferase ZDHHC5 Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. 10.7 9.6 4.5 ND ND ND
345792339 Pleckstrin homology domain-containing family A member 5 Unknown function. 8.2 6.0 4.7 ND ND 13.0
345790319 Probable palmitoyltransferase ZDHHC20 Membrane enzyme. 7.8 1.7 8.1 ND ND ND
73963551 Protein numb homolog Membrane protein with a role in determination of cell fates during development and neurogenesis. May have a role in Notch signaling pathway. 5.7 ND ND ND ND 6.5
50979052 Annexin A13 Associated with the plasma membrane of crypt epithelial cells and villus enterocytes. 3.7 (1.0) 25.5 ND ND ND
359322167 Paralemmin-1 Involved in plasma membrane dynamics, synapse maturation, spine formation and recruitment of AMPA-type glutamate receptors. 3.2 2.5 (2.5) ND ND ND [123]
73950747 Transmembrane protein 51 Membrane protein with unknown function. 3.2 2.2 5.3 ND ND ND
73967304 345804993 Carboxypeptidase D Enzyme. Releases C-terminal Arg and Lys from polypeptides. 3.1 (1.1) 4.5 ND ND 0.6
345793135 Junctophilin-1 Links the plasma membrane with the ER or sarcoplasmic reticulum. (2.7) 3.4 (1.1) ND ND 0.8
73987612 Basigin Plays an important role in targeting the monocarboxylate transporters to the plasma membrane. (2.6) (0.7) 28.2 ND ND (0.4)
345796185 Pleckstrin homology-like domain, family B, member 2 May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane. (2.2) 2.1 (0.6) ND ND ND
345779148 Protein EFR3 homolog A A component of a protein complex required for the synthesis of the phosphoinositide PtdIns4P, which has a variety of functions at the neural synapse. Localizes at the plasma membrane. (1.2) 2.2 (1.5) ND ND 1.6
73981384 345782539 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. ND ND 8.7 ND ND ND
345784192 Membrane-associated progesterone receptor component 2 Membrane steroid receptor. ND ND 5.3 ND ND 3.9
345781880 Syndecan-1 Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. ND ND 4.5 ND ND ND