Table 4. Literature on the sensitivity and specificity of screening test using HbA1c in general populations.
| Study (First author, year, reference) | Country | Sample Size | Age Range | Screening Test | Sensitivity | Specificity | Gold Standard Test |
|---|---|---|---|---|---|---|---|
| Pre-diabetes | |||||||
| Lee, 2013 [45] | Korea | 4,616 | >18 y | HbA1c (≥5.7%) | 48.6% | 65.7% | OGTT |
| Colagiuri, 2004 [38] | Australia | 10,477 | >25 y | HbA1c (≥5.3%) | 42.0% | 88.2% | OGTT |
| Mannucci, 2003 [43] | Italy | 1,215 | 30–70 y | HbA1c (>5.5%) or FPG (>6.1 mmol/l) | 59.0% (M) 54.8% (F) | 19.3% (M) 9.3% (F) | OGTT |
| Saydan, 2002 [44] | US | 2,844 | 40–74y | FPG (≥6.1 mmol/l) or HbA1c (≥5.5%) | 45.5% | 81.3% | OGTT |
| Saydan, 2002 [44] | US | 2,844 | 40–74y | HbA1c (≥6.0%) | 16.7% | 92.9% | OGTT |
| Diabetes | |||||||
| Buell, 2007 [15] | US | 4,935 | ≥20 y | HbA1c (≥5.8%) | 86.0% | 92.0% | FPG |
| Nakagami, 2007 [41] | Japan | 1,904 | 35–89 y | HbA1c (≥5.6%) | 56.5% | 96.1% | FPG |
| Droumaguet, 2006 [42] | France | 2,820 | 30–65 y | HbA1c (≥6.3%) | 77.0% | 86.0% | FPG |
| Colagiuri, 2004 [38] | Australia | 10,447 | >25 y | HbA1c (≥5.3%) and RF | 78.7% | 82.8% | OGTT |
RF: risk factor
“And”: two tests were conducted sequentially
“Or”: two tests were conducted simultaneously