Table 2. Association between cancer GWAS SNPs and melanoma.
Table 2a) | |||||||||
---|---|---|---|---|---|---|---|---|---|
SNP | Gene | Chromosome / Risk allele | Original cancer association | n | # Studies | OR | 95% CI | p-value | p-hetero-geneity |
rs4975616 | TERT/CLPTM1L | 5 / A | Lung cancer | 22,135 | 5 | 0.87 | (0.81–0.93) | 2.30E-05 | 0.78 |
rs401681 | TERT/CLPTM1L | 5 / C | Lung cancer | 22,109 | 5 | 0.87 | (0.81–0.93) | 3.65E-05 | 0.70 |
2a) SNPs showing a statistically significant association with melanoma at a Bonferroni-corrected threshold of 0.05/181 = 2.8x10-4.
2b) SNPs showing a marginal association with melanoma at p<0.05.