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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Invest Dermatol. 2014 Nov 17;135(4):1184–1187. doi: 10.1038/jid.2014.486

Figure 1. Topical Hesperidin Improves Epidermal Permeability Barrier Homeostasis in Aged Murine Skin.

Figure 1

The values present the data in vivo in mice unless otherwise specified. Figure 1a displays basal TEWL and skin surface pH in mice; 1b, barrier recovery in mice; Fig. 1c shows the levels of epidermal mRNA in mice; 1d exhibits the levels of mRNA expression in vitro in human keratinocyte cultures, expressed as % of vehicle treated samples setting the levels of vehicle treated as 100% (dotted line); Fig. 1e shows epidermal mRNA levels in mice, expressed as % of normal young mice setting the levels of young mice as 100% (dotted line); Fig. 1f is the results of quantitative analysis of lamellar body density and secretion in mice; Fig. 1g and h present the expression levels of ABCA12 in mice and in vitro in human keratinocyte cultures, respectively; Fig. 1i shows the expression levels of epidermal NHE1 and sPLA2 in mice. Significances and numbers of samples are indicated in the figures.