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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Inflamm Bowel Dis. 2015 Apr;21(4):912–922. doi: 10.1097/MIB.0000000000000289

Figure 1. Genetics, microbes, and diet act in concert to maintain intestinal homeostasis.

Figure 1

Components in each of these categories can affect intestinal function directly, as well as synergize with other categories to influence overall intestinal health. Alteration of any single component is not sufficient to cause IBD. However, consumption of a Western diet may act in combination with microbes and genetic susceptibility to accelerate IBD pathogenesis.