Table 2.
Association testing with a sample structure and environmental factor, and , σ2 = 40 based on the T2D-GENES genotype data. 959 samples were artificially assigned into 2 clusters.
EMMAX | GEMMA | PCR
|
hybrid | OLS | ||||||
---|---|---|---|---|---|---|---|---|---|---|
20 | 40 | 60 | 80 | 100 | ||||||
θ1 = −1, θ2 = 1 | Type I | 0.057 | 0.059 | 0.081 | 0.067 | 0.065 | 0.061 | 0.059 | 0.052 | 0.152 |
λ | 1.133 | 1.146 | 1.302 | 1.218 | 1.152 | 1.125 | 1.097 | 1.076 | 1.947 | |
θ1 = −2, θ2 = 2 | Type I | 0.073 | 0.075 | 0.092 | 0.070 | 0.068 | 0.062 | 0.061 | 0.053 | 0.288 |
λ | 1.279 | 1.299 | 1.381 | 1.237 | 1.175 | 1.139 | 1.113 | 1.093 | 3.823 | |
θ1 = −4, θ2 = 4 | Type I | 0.107 | 0.109 | 0.136 | 0.083 | 0.077 | 0.070 | 0.067 | 0.061a | 0.626 |
λ | 1.629 | 1.645 | 1.769 | 1.334 | 1.275 | 1.208 | 1.151 | 1.158a | 11.976 |
For PC#=40, 60, 80, 100, Type I errors=0.056, 0.055, 0.053, 0.051 and λ =1.111, 1.060, 1.062, 1.063 respectively.