Figure 4. Inhibiting neuronal excitability suppresses Aβ accumulation induced by sleep loss.
Daytime and nighttime sleep amounts (A), representative maximum projection images of KC from whole-mount brains immunostained with 6E10 (B–E), and normalized Aβ signal intensity in the MB KC neurons (F) for OK107-Gal4>UAS-AβArctic, UAS-dORKΔNC without sleep deprivation (n=20) and with sleep deprivation (n=13) and OK107-Gal4>UAS-AβArctic, UAS-dORKΔC2 without sleep deprivation (n=17) and with sleep deprivation (n=13). Scale bar represents 100 μm.