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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2015 Apr;74(4):370–379. doi: 10.1097/NEN.0000000000000180

Figure 4.

Figure 4

Tau band pattern in sarkosyl-insoluble fractions of the temporal cortex (Tc), temporal white matter (Twm), and hippocampus (Hip) in astrocyte-predominant familial tauopathy processed in parallel with a case of Alzheimer disease (AD) stage V of Braak and Braak for comparison. Two main bands of 64 and 60 kDa, as revealed with antibodies Tau-P Ser422 and AT8, are observed in temporal cortex and white matter, and hippocampus in astrocyte-predominant familial tauopathy in contrast with the three bands of 68, 64 and 60 kDa characteristically found in AD. In addition, a doublet between 67 and 70 kDa, instead of the band of 68 kDa of AD, is found in astrocyte-predominant familial tauopathy. This doublet differs from the additional thin weak band of 73 kDa characteristically occurring in AD. Finally, several bands of lower molecular weight are indicative of several truncated tau species.