Table 2.
| A. Comparison of the association of HLA-C*06:02 and rs4406273-A with psoriasis for samples successfully typed for both markers.
| |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cohort | n | HLA-C*06:02
|
rs4406273-A
|
||||||
| allele frequency
|
OR | p-value | allele frequency
|
OR | p-value | ||||
| cases | controls | cases | controls | ||||||
| Michigan | 5009 | 0.2327 | 0.0900 | 3.41 | 8.5 × 10−83 | 0.2307 | 0.0896 | 3.38 | 1.8 × 10−81 |
| Pakistan | 835 | 0.2484 | 0.1257 | 2.42 | 1.8 × 10−10 | 0.2390 | 0.1248 | 2.32 | 1.6 × 10−9 |
| Thailand | 307 | 0.1766 | 0.0425 | 5.38 | 7.5 × 10−6 | 0.1791 | 0.0472 | 4.91 | 1.0 × 10−5 |
| B. Conditional haplotype testing of independent effects for samples successfully typed for both HLA-C*06:02 and rs4406273
| ||||
|---|---|---|---|---|
| Test marker | Conditioning marker | Independent effects p-value
|
||
| Michigan | Pakistan | Thailand | ||
| HLA-C*06:02 | rs4406273 | 0.0052 | 0.011 | 0.20 |
| rs4406273 | HLA-C*06:02 | 0.20 | 0.11 | 0.82 |