Table 2.

Association of high stress and depressive symptoms evaluated separately on myocardial infarction or death, REGARDS (N = 4,487).

	Hazard ratio (95% confidence interval)
	Model 1	Model 2	Model 3
First 2.5 years of follow-up
High stress versus low stress	1.22 (0.94 – 1.57)	1.20 (0.93 – 1.55)	1.20 (0.93 – 1.55)
High depressive symptoms versus low depressive symptoms	1.30 (1.02 – 1.64)	1.22 (0.96 – 1.55)	1.16 (0.92 – 1.47)
> 2.5 years of follow-up
High stress versus low stress	1.03 (0.83 – 1.28)	1.01 (0.81 – 1.25)	1.01 (0.81 – 1.25)
High depressive symptoms versus low depressive symptoms	0.98 (0.80 – 1.21)	0.92 (0.75 – 1.13)	0.88 (0.72 – 1.09)

Model 1 adjusted for race, age, sex, region of residence, body mass index, income, education, marital status, general self-rated health, hypertension, diabetes, history of myocardial infarction and stroke.

Model 2 adjusted for all covariates in Model 1 and use of statins, beta blockers, aspirin, antidepressants, clopidogrel and renin angiotensin system inhibitors.

Model 3 adjusted for all in Model 1 and Model 2 and physical activity, alcohol consumption, cigarette smoking, and medication adherence.

REGARDS (Reason for Geographic and Racial Differences in Stroke).