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Mean (±SE) discharge rates (impulses/s) for all WDR (A) and HT (B) neurons evoked by application of 37.3 mN, 73.6 mN and 135.3 mN von Frey filaments in control and sickle mice. Responses evoked by the 73.6 mN and 135.3 mN stimuli were greater for WDR neurons in sickle mice whereas responses to each of the forces was greater in sickle mice. *P < 0.05; **P < 0.01).
