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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Pain. 2015 Apr;156(4):722–730. doi: 10.1097/j.pain.0000000000000104

Figure 4.

Figure 4

Mechanical stimulation evokes prolonged afterdischarges in nociceptive neurons in sickle mice. Upper panels show responses evoked by the 135.3 mN force in a WDR neuron from a control mouse (A) and from a sickle mouse (B). Similarly, responses of single HT neurons from a control and from a sickle mouse are shown in C and D. Horizontal lines represent the time of stimulus application. The location of the RF is shown for each neuron. Discriminated output pulses from a window discriminator are provided below the histograms. Responses to mechanical stimulation were greater and prolonged in sickle mice. Bin width of the peristimulus time histograms is 250 ms.