Table 1.

Mutations proposed to confer macrophage tropism are not observed in a well-validated collection of macrophage-tropic clones

Env amino acid changes thought to convey macrophage tropism
Patient	Tropism	153	167	238b	240	283	308	317	326	373	386	396
Consensus (sub. B)	Tcell	E	D	P	T	T	H	F	I	M	N*	N*
Proposed mutation	Macrophage	Ga	Na	Kb	Kb	Nc,d	Pe	Ld	(M→I)b	Kf	Xf,g	Xh
4013	T cell	–	–	L	R	–	P	–	–	–	–	K
4013	Macrophage	–	–	–	–	–	–	I	–	–	–	–
4051	T cell	–	–	–	–	–	P	–	–	T	–	–
4051	Macrophage	–	–	L	K	–	P	–	–	T	T	–
4059	T cell	–	N	E	K	–	N	W	–	–	–	T
4059	Macrophage	–	N	E	K	–	S	W	–	–	–	T
5002	T cell	–	–	–	–	I	–	–	T	–	–	–
5002	Macrophage	D	–	–	–	–	–	–	–	–	–	–
7115	T cell	–	–	–	K	–	–	–	–	–	–	–
7115	Macrophage	–	–	–	K	–	–	–	–	–	–	–

^aMusich et al. (2011)

^bCashin et al. (2011)

^cDunfee et al. (2006)

^dDuenas-Decamp et al. (2009)

^eThomas et al. (2007)

^fDuenas-Decamp et al. (2008)

^gDunfee et al. (2007)

^hOuyang et al. (2014)