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. 2015 Mar 19;10(3):e0121089. doi: 10.1371/journal.pone.0121089

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© 2015 Halbach et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — (A) In HeLa cells overexpressing Cherry-GFP-PARK2 and FBXW8-HA, pulling with anti-FBXW8 antibody resulted in the detection of FBXW8 as well as of PARK2 in Co-IP lysates, demonstrating their interaction (experiment repeated twice, representative image). (B) PARK2 interacts with FBXW8 in Co-IP samples of Atxn2-CAG42-KIN mice independent of the polyQ length. Lower bands represent PARK2 protein (experiment repeated once). (C) PARK2 protein level is decreased in the RIPA-soluble fraction while it is increased in the SDS-soluble fraction (8 Atxn2 ^CAG1/CAG1 mice vs. ≥ 6 Atxn2 ^CAG42/CAG42 mice).