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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Angiogenesis. 2014 Nov 25;18(2):137–150. doi: 10.1007/s10456-014-9451-4

Figure.6. Candesartan restored hemeoxygenase-1 expression in hypoxia.

Figure.6

Quantitative data of gene expression of the antioxidants; (A) total thioredoxin (TRX) mRNA and (B) hemoxygenase (HO-1) mRNA levels. In hypoxia, TRX mRNA expression significantly increased but there was no change in HO-1 compared to normoxia. Treatment with candesartan partially but not significantly reduced TRX level compared to hypoxia alone. (C-D) Representative immunoblots and relative density showing that hypoxia significantly reduced HO-1 expression compared to normoxia. Treatment with candesartan significantly induced HO-1 mRNA and protein levels in normoxia and hypoxia. Two-way ANOVA showed significant interaction between candesartan and hypoxia in retinal HO-1 protein level, *p<0.05 vs control, # p<0.05 vs hypoxia, n=6-8/group.