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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Angiogenesis. 2014 Nov 25;18(2):137–150. doi: 10.1007/s10456-014-9451-4

Figure.7. Candesartan enhanced HO-1 expression under normoxia and hypoxia in retinal endothelial cells.

Figure.7

Representative images and quantification of HO-1 and VEGF expression levels after 24 hours in normoxia (A, B, C), and hypoxia (D, E, F) in presence or absence of candesartan at (1μg/ml). Candesartan treatment increased levels of HO-1 in normoxia and hypoxia scramble group but not in siRNA group. Candesartan treatment tended to increase VEGF expression in normoxia but not in hypoxia. Scr-Ctrl: Scramble- control, Scr-Cand: Scramble- candesartan, siRNA- Ctrl: siRNA control, siRNA- Cand: siRNA candesartan. Two-way ANOVA showed significant interaction between candesartan and gene silencing in HO-1 protein level in EC, *p<0.05 vs Scr-Ctrl, n=3-6/group.